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The TBS group was later recovered with tetra- normal-butylammonium fluoride TBAF in THF to give alcohol 28 in 91 yields.

A simple synthetic procedure allows the conversion of a wide variety of carboxylic acid to hydroxamates. Synthesis of Weinreb Amides Using Triazime Intermediates De Luca et al 37 reported the successful large scale synthesis of weinreb amide through a convenient and simple one-flask method via 2-chloro-4,6-dimethoxy-1,3,5-triazine intermediate 20.

Oxidation of alcohol 24 under Swern condition 47 gave aldehyde 25 which was treated with an aryl Grignard reagent to produce alcohol 26.

Alcohol 26 was treated with 2-methoxy propene and pyridinium p-toluenesulfonate PPTS to generate protected diol 27.

HDAC performs the reverse process of histone acetyl co A to the lysines on the histone, inducing a state known as hyper acetylation.

Hyper acetylation causes a decreased binding of the histones to DNA and leads to chromatin expansion, allowing transcription to take place.

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